Overview

Description

  • NatureSynthetic

Associated products

Specifications

Our Abpromise guarantee covers the use of ab90246 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Purity70 - 90% by HPLC.

  • FormLiquid
  • Additional notes

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

General Info

  • Alternative names
    • Lymphocyte function associated antigen, type 1, alpha subunit
    • Antigen CD11A
    • Antigen CD11A (p180), lymphocyte function associated antigen 1, alpha polypeptide
    • CD 11a
    • CD11 antigen-like family member A
    • CD11a
    • CD11a antigen
    • Integrin Alpha L
    • Integrin alpha-L
    • Integrin gene promoter
    • Integrin, alpha L (antigen CD11A (p180), lymphocyte function associated antigen 1; alpha polypeptide)
    • ITAL_HUMAN
    • Itgal
    • ITGAL protein
    • Leukocyte adhesion glycoprotein LFA 1 alpha chain
    • Leukocyte adhesion glycoprotein LFA-1 alpha chain
    • Leukocyte Adhesion Glycoprotein LFA1 Alpha Chain
    • Leukocyte function associated molecule 1 alpha chain
    • Leukocyte function-associated molecule 1 alpha chain
    • LFA 1
    • LFA 1 alpha
    • LFA 1 alpha (LFA1A)
    • LFA 1A
    • LFA-1A
    • LFA1A
    • Ly15
    • Ly21
    • Lymphocyte function associated antigen 1
    • Lymphocyte Function Associated Antigen Type 1 alpha
    • lymphocyte function-associated antigen 1, alpha polypeptide
    • p180
    see all
  • FunctionIntegrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.
  • Tissue specificityLeukocytes.
  • Sequence similaritiesBelongs to the integrin alpha chain family.
    Contains 7 FG-GAP repeats.
    Contains 1 VWFA domain.
  • DomainThe integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
  • Cellular localizationMembrane.
  • Information by UniProt

References for Human CD11a peptide (ab90246)

ab90246 has not yet been referenced specifically in any publications.

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The product ab90246 is a 20 amino acid synthetic peptide corresponding to a region within amino acids 950-1050 of human CD11a. Unfortunately, since this peptide was used as an immunogen for ab78058, the exact sequ...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"