Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      C-QDQESSPIENDSSP
    • Amino acids
      284 to 297

Associated products

Specifications

Our Abpromise guarantee covers the use of ab22803 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-CD20 antibody (ab1310)

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • APY
    • ATOPY
    • B lymphocyte antigen CD20
    • B Lymphocyte Cell Surface Antigen B1
    • B-lymphocyte antigen CD20
    • B-lymphocyte cell-surface antigen B1
    • B-lymphocyte surface antigen B1
    • B1
    • Bp 35
    • Bp35
    • CD 20
    • CD20
    • CD20 antigen
    • CD20 receptor
    • CD20_HUMAN
    • CVID5
    • Fc epsilon receptor I beta chain
    • Fc Fragment of IgE high affinity I receptor for beta polypeptide
    • FCER1B
    • High affinity immunoglobulin epsilon receptor subunit beta
    • IgE Fc receptor subunit beta
    • IGEL
    • IGER
    • IGHER
    • LEU 16
    • LEU16
    • leukocyte surface antigen Leu 16
    • Leukocyte surface antigen Leu-16
    • Ly44
    • Membrane spanning 4 domains A1
    • Membrane spanning 4 domains subfamily A member 2
    • Membrane-spanning 4-domains subfamily A member 1
    • MGC3969
    • MS4A1
    • MS4A2
    • S7
    see all
  • Function
    This protein may be involved in the regulation of B-cell activation and proliferation.
  • Tissue specificity
    Expressed on B-cells.
  • Involvement in disease
    Defects in MS4A1 are the cause of immunodeficiency common variable type 5 (CVID5) [MIM:613495]; also called antibody deficiency due to CD20 defect. CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.
  • Sequence similarities
    Belongs to the MS4A family.
  • Post-translational
    modifications
    Phosphorylated. Might be functionally regulated by protein kinase(s).
  • Cellular localization
    Membrane.
  • Information by UniProt

References

ab22803 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Unfortunately, neither of these peptides overlap with the binding site recognized by Rituximab, which according to the reference PMID 16705086 bind to a discontiguous epitope comprised of amino acids 170-173 and 1...

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