Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceC-PLLNTQEPMEPAE
    • Amino acids824 to 836

Specifications

Our Abpromise guarantee covers the use of ab22864 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General info

  • Alternative names
    • 9030022E12Rik
    • AA409659
    • CD 318
    • CD_antigen=CD318
    • CD318
    • CD318 antigen
    • CDCP 1
    • Cdcp1
    • CDCP1_HUMAN
    • CUB Domain Containing Protein 1
    • CUB domain-containing protein 1
    • E030027H19Rik
    • FLJ13772
    • FLJ22375
    • FLJ22969
    • Membrane glycoprotein gp140
    • MGC31813
    • OTTHUMP00000164120
    • OTTHUMP00000209568
    • RGD1305578
    • SIMA 135
    • SIMA135
    • Subtractive immunization M plus HEp3 associated 135 kDa protein
    • Subtractive immunization M plus HEp3-associated 135 kDa protein
    • Transmembrane and associated with src kinases
    • TRASK
    see all
  • FunctionMay be involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis.
  • Tissue specificityHighly expressed in mitotic cells with low expression during interphase. Detected at highest levels in skeletal muscle and colon with lower levels in kidney, small intestine, placenta and lung. Up-regulated in a number of human tumor cell lines, as well as in colorectal cancer, breast carcinoma and lung cancer. Also expressed in cells with phenotypes reminiscent of mesenchymal stem cells and neural stem cells.
  • Sequence similaritiesContains 1 CUB domain.
  • Post-translational
    modifications
    Phosphorylated on tyrosine by kinases of the SRC family such as SRC and YES as well as by the protein kinase C gamma/PRKCG. Dephosphorylated by phosphotyrosine phosphatases. Also phosphorylated by suramin, a heparin analog. Tyrosine phosphorylated in response to dissociation of integrin alpha-6 beta-4 from laminin-5.
    N-glycosylated.
    A soluble form may also be produced by proteolytic cleavage at the cell surface (shedding). Another peptide of 80 kDa (p80) is present in cultured keratinocytes probably due to tryptic cleavage at an unidentified site on its N-terminal side. Converted to p80 by plasmin, a trypsin-like protease.
  • Cellular localizationSecreted and Cell membrane. Shedding may also lead to a soluble peptide.
  • Information by UniProt

References for Human CDCP1 peptide (ab22864)

ab22864 has not yet been referenced specifically in any publications.

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