The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-CED6 antibody (ab2751)
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Cell death protein 6 homolog
Engulfment adapter protein
Engulfment adaptor PTB domain containing 1
GULP, engulfment adaptor PTB domain containing 1
PTB domain adapter protein CED 6
PTB domain adapter protein CED-6
PTB domain adaptor protein CED6
PTB domain-containing engulfment adapter protein 1
FunctionMay function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6.
Tissue specificityWidely expressed. Detected in macrophages, pancreas, kidney, skeletal muscle, heart, colon, intestine, lung, placenta and ovary.
Sequence similaritiesBelongs to the ced-6 family. Contains 1 PID domain.
Cellular localizationCytoplasm. May associate with the cytoplasmic side of the plasma membrane and early endosomes.