Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceC-EKLSRRSHDLHTL
    • Amino acids728 to 740

Associated products

Specifications

Our Abpromise guarantee covers the use of ab23280 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-CENTB1 antibody (ab15903)

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • ACAP 1
    • ACAP1
    • ACAP1_HUMAN
    • Arf GAP with coiled coil ANK repeat and PH domains 1
    • Arf GAP with coiled coil, ankyrin repeat, and pleckstrin homology domains 1
    • Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1
    • ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
    • CENT B1
    • Centaurin beta 1
    • Centaurin-beta-1
    • CENTB 1
    • Cnt b1
    • Cnt-b1
    • Cntb1
    • KIAA0050
    see all
  • FunctionGTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface.
  • Tissue specificityHighest level in lung and spleen. Low level in heart, kidney, liver and pancreas.
  • Sequence similaritiesContains 3 ANK repeats.
    Contains 1 Arf-GAP domain.
    Contains 1 BAR domain.
    Contains 1 PH domain.
  • DomainPH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate ACAP1-binding to PIP2 or PIP3 containing membranes.
  • Post-translational
    modifications
    Phosphorylation at Ser-554 by PKB is required for interaction with ITGB1, export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration.
  • Information by UniProt

References for Human CENTB1 peptide (ab23280)

ab23280 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab23280.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"