The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-CLLD8/SETDB2 antibody (ab13712)
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Chromosome 13 open reading frame 4
Chronic lymphocytic leukemia deletion region 8
Chronic lymphocytic leukemia deletion region gene 8
Chronic lymphocytic leukemia deletion region gene 8 protein
Histone H3-K9 methyltransferase
Histone-lysine N-methyltransferase SETDB2
Lysine N-methyltransferase 1F
Probable histone-lysine N-methyltransferase H3 lysine-9 specific
SET domain bifurcated 2
SET domain protein, bifurcated, 2
FunctionHistone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis.
Tissue specificityUbiquitous. Highest expression in heart, testis and ovary.
Sequence similaritiesBelongs to the histone-lysine methyltransferase family. Contains 1 MBD (methyl-CpG-binding) domain. Contains 1 pre-SET domain. Contains 1 SET domain.