Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • AccessionQ96T68
    • SpeciesHuman
    • SequenceGEKNGDAKTFWME-C
    • Amino acids2 to 14

Associated products

Specifications

Our Abpromise guarantee covers the use of ab23232 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-CLLD8/SETDB2 antibody (ab13712)

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • C13orf4
    • Chromosome 13 open reading frame 4
    • Chronic lymphocytic leukemia deletion region 8
    • Chronic lymphocytic leukemia deletion region gene 8
    • Chronic lymphocytic leukemia deletion region gene 8 protein
    • Clld8
    • CLLL8
    • Gm293
    • H3-K9-HMTase
    • Histone H3-K9 methyltransferase
    • Histone-lysine N-methyltransferase SETDB2
    • KMT1F
    • Lysine N-methyltransferase 1F
    • Probable histone-lysine N-methyltransferase H3 lysine-9 specific
    • SEB2
    • SET domain bifurcated 2
    • SET domain protein, bifurcated, 2
    • SETB2_HUMAN
    • Setdb2
    see all
  • FunctionHistone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis.
  • Tissue specificityUbiquitous. Highest expression in heart, testis and ovary.
  • Sequence similaritiesBelongs to the histone-lysine methyltransferase family.
    Contains 1 MBD (methyl-CpG-binding) domain.
    Contains 1 pre-SET domain.
    Contains 1 SET domain.
  • Cellular localizationNucleus. Chromosome.
  • Information by UniProt

References for Human CLLD8/SETDB2 peptide (ab23232)

ab23232 has not yet been referenced specifically in any publications.

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