Human CNTROB protein fragment (ab91887)
- Product nameHuman CNTROB protein fragment
- SourceE. coli
- Amino Acid Sequence
- SequenceKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYE LRLAREQ ARVCELQSGNQQLEEQRVELVERLQAMLQAH WDEANQLLSTTLPPPN PPAPPAGPSSPGPQEPEKEERR VWTMPPMAVALKPVLQQSREARDEL PGAPPVLCSSSSD LSLLLGPSFQSQHSFQPLEPKPDLTSSTAGAFSA LGAF HPDHRAERPFPEEDPGPDGEGLLKQGLPPAQLEGLKNFLH QLL ETVPQNNENPSVDLLPPKSGPLTVPSWEEAPQVPR IPPPVHKTKVPL AMASSLFRVPEPPSSHSQGSGPSSGS PERGGDGLTFPRQLMEVSQLL RLYQARGWGALPAEDLL LYLKRLEHSGTDGRGDNVPRRNTDSRLGEI PRKEIPSQ AVPRRLATAPKTEKPPARKKSGHPAPSSMRSRGGVWR
- Amino acids483 to 903
Our Abpromise guarantee covers the use of ab91887 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- Additional NotesProtein Identity confirmed by Mass Spectrometry (MS/MS) (acquired on initial reference batch)
- Concentration information loading...
Preparation and Storage
- Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
Constituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
- ReconstitutionReconstitute with 113 µl distilled water.
- centrobin, centrosomal BRCA2 interacting protein
- Centrosomal BRCA2 interacting protein
- Centrosomal BRCA2-interacting protein
- LYST interacting protein 8
- LYST-interacting protein 8
- RP23 26L6.9
- FunctionRequired for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis.
- Tissue specificityWidely expressed (at protein level). Highly expressed in testis. Also expressed in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes.
- Developmental stagePreferentially incorporated into the newly assembled daughter centriole during centriole assembly at the late G1 or early S phase. Remains in the daughter centrioles throughout the cell cycle. At the next cycle of centriole duplication, its amount on the original daughter centriole eventually decreases.
modificationsPhosphorylated upon DNA damage, probably by ATM or ATR.
- Cellular localizationCytoplasm > cytoskeleton > centrosome > centriole. Centriole-associated, asymmetrically localizes to the daughter centriole.
Human CNTROB protein fragment images
The image shows an electrophoretic assay performed using an Agilent 5100 ALP. In some images coloured control bands can be seen at 15 kDa (green) and/or 240 kDa (purple). The protein-specific band is blue.
References for Human CNTROB protein fragment (ab91887)
ab91887 has not yet been referenced specifically in any publications.