Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      C-ETLGLSAGPIPGN
    • Amino acids
      85 to 97

Specifications

Our Abpromise guarantee covers the use of ab22869 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • CAR16_HUMAN
    • CARD only domain-containing protein 1
    • CARD only protein
    • CARD16
    • Caspase recruitment domain family, member 16
    • Caspase recruitment domain-containing protein 16
    • Caspase-1 dominant-negative inhibitor pseudo-ICE
    • Caspase-1 inhibitor COP
    • COP
    • COP1
    • Pseudo interleukin 1 beta converting enzyme
    • Pseudo interleukin-1 beta converting enzyme
    • Pseudo interleukin-1beta converting enzyme
    • PSEUDO-ICE
    see all
  • Function
    Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2.
  • Tissue specificity
    Widely expressed. Expressed at higher level in placenta, spleen, lymph node and bone marrow. Weakly or not expressed in thymus.
  • Sequence similarities
    Contains 1 CARD domain.
  • Information by UniProt

References

ab22869 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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