Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      LETLKDICSPKTDY
    • Amino acids
      287 to 300

Associated products

Specifications

Our Abpromise guarantee covers the use of ab45635 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-CREM antibody (ab23940)

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

General Info

  • Alternative names
    • cAMP response element modulator
    • cAMP responsive element modulator
    • cAMP-responsive element modulator
    • CREM
    • CREM-2
    • CREM_HUMAN
    • hCREM 2
    • hCREM-2
    • hCREM2
    • ICER
    • Inducible cAMP early repressor
    • Inducible cAMP early repressor ICER
    • MGC111110
    • MGC17881
    • MGC41893
    see all
  • Function
    Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation.
  • Tissue specificity
    Expressed in testes (round spermatids) (at protein level). Isoform 14 is the major activator form in testes.
  • Sequence similarities
    Belongs to the bZIP family.
    Contains 1 bZIP (basic-leucine zipper) domain.
    Contains 1 KID (kinase-inducible) domain.
  • Post-translational
    modifications
    Isoform 9 is ubiquitinated by CDC34 and RAD6B in order to be degraded by the proteasome.
    Stimulated by phosphorylation.
  • Cellular localization
    Nucleus.
  • Information by UniProt

References

ab45635 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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