Overview

Description

  • Nature
    Synthetic

Associated products

Specifications

Our Abpromise guarantee covers the use of ab99478 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Purity
    70 - 90% by HPLC.

  • Form
    Liquid
  • Additional notes

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

General Info

  • Alternative names
    • Collapsin response mediator protein
    • Collapsin response mediator protein 2
    • Collapsin response mediator protein hCRMP 2
    • CRAM
    • CRMP 2
    • CRMP-2
    • CRMP2
    • DHPRP 2
    • DHPRP2
    • Dihydropyrimidinase 2
    • Dihydropyrimidinase like 2
    • Dihydropyrimidinase like 2 long form
    • Dihydropyrimidinase related protein 2
    • Dihydropyrimidinase-related protein 2
    • DPYL 2
    • DPYL2
    • DPYL2_HUMAN
    • DPYSL 2
    • Dpysl2
    • DRP-2
    • DRP2
    • Musunc 33
    • Musunc33
    • N2A3
    • TOAD 64
    • TOAD64
    • ULIP 2 protein
    • ULIP-2
    • Ulip2
    • Unc-33-like phosphoprotein 2
    see all
  • Function
    Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration.
  • Tissue specificity
    Ubiquitous.
  • Sequence similarities
    Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.
  • Post-translational
    modifications
    3F4, a monoclonal antibody which strongly stains neurofibrillary tangles in Alzheimer disease brains, specifically labels DPYSL2 when phosphorylated on Ser-518, Ser-522 and Thr-509.
  • Cellular localization
    Cytoplasm.
  • Information by UniProt

References

ab99478 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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