Overview

Description

  • Nature
    Synthetic

Specifications

Our Abpromise guarantee covers the use of ab24280 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form
    Liquid
  • Additional notes

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

General Info

  • Alternative names
    • C-X-C chemokine receptor type 2
    • CD 182
    • CD182
    • CD182 antigen
    • CDw128b
    • Chemokine (CXC) receptor 2
    • CMKAR2
    • CXC-R2
    • CXCR 2
    • CXCR-2
    • CXCR2
    • CXCR2_HUMAN
    • GRO/MGSA receptor
    • High affinity interleukin-8 receptor B
    • IL 8 receptor type 2
    • IL 8R B
    • IL-8 receptor type 2
    • IL-8R B
    • IL8 RB
    • IL8 receptor type 2
    • IL8R B
    • IL8R2
    • IL8RA
    • Interleukin 8 Receptor B
    • Interleukin 8 receptor, beta
    • Interleukin 8 receptor, type 2
    see all
  • Function
    Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.
  • Sequence similarities
    Belongs to the G-protein coupled receptor 1 family.
  • Post-translational
    modifications
    Phosphorylated upon ligand binding; which is required for desensitization.
  • Cellular localization
    Cell membrane.
  • Information by UniProt

References

ab24280 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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