Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      HQQDKAQKQEDKH

Specifications

Our Abpromise guarantee covers the use of ab45481 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

General Info

  • Alternative names
    • CAP GLY domain containing linker protein 2
    • CAP-Gly domain-containing linker protein 2
    • CLIP
    • CLIP 115
    • CLIP-115
    • Clip2
    • CLIP2_HUMAN
    • cytoplasmic linker 2
    • Cytoplasmic linker protein 115
    • Cytoplasmic linker protein 2
    • KIAA0291
    • MGC11333
    • restin
    • Similar to RESTIN (CYTOPLASMIC LINKER PROTEIN 170 ALPHA 2)
    • WBSCR3
    • WBSCR4
    • Williams Beuren syndrome chromosome region 3
    • Williams Beuren syndrome chromosome region 4
    • Williams-Beuren syndrome chromosomal region 3 protein
    • Williams-Beuren syndrome chromosomal region 4 protein
    • WSCR3
    • WSCR4
    see all
  • Function
    Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operates in the control of brain-specific organelle translocations.
  • Involvement in disease
    Note=CLIP2 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of CLIP2 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.
  • Sequence similarities
    Contains 2 CAP-Gly domains.
  • Cellular localization
    Cytoplasm. Cytoplasm > cytoskeleton. Associated with the cytoskeleton.
  • Information by UniProt

References

ab45481 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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