Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      C-YPDSDVLFRYKVKS
    • Amino acids
      493 to 506

Associated products

Specifications

Our Abpromise guarantee covers the use of ab45557 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-CYP7B1 antibody (ab19043)

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

General Info

  • Alternative names
    • 25 hydroxycholesterol 7 alpha hydroxylase
    • 25-hydroxycholesterol 7-alpha-hydroxylase
    • CP7B
    • CP7B1_HUMAN
    • Cyp7b1
    • Cytochrome P450 7B1
    • Cytochrome P450 family 7 subfamily B polypeptide 1
    • Cytochrome P450 subfamily VIIB polypeptide 1
    • Oxysterol 7-alpha-hydroxylase
    • Oxysterol 7alpha hydroxylase
    see all
  • Tissue specificity
    Brain, testis, ovary, prostate, liver, colon, kidney, and small intestine.
  • Pathway
    Lipid metabolism; bile acid biosynthesis.
  • Involvement in disease
    Defects in CYP7B1 are the cause of spastic paraplegia autosomal recessive type 5A (SPG5A) [MIM:270800]. Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body.
    Defects in CYP7B1 are the cause of congenital bile acid synthesis defect type 3 (CBAS3) [MIM:613812]. Clinical features include severe cholestasis, cirrhosis and liver synthetic failure. Hepatic microsomal oxysterol 7-alpha-hydroxylase activity is undetectable.
  • Sequence similarities
    Belongs to the cytochrome P450 family.
  • Cellular localization
    Endoplasmic reticulum membrane. Microsome membrane.
  • Information by UniProt

References

ab45557 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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