The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Cytochrome P450 17A1
Cytochrome P450 family 17
Cytochrome P450 family 17 subfamily A polypeptide 1
Cytochrome p450 subfamily XVII (steroid 17 alpha hydroxylase) adrenal hyperplasia
Cytochrome p450 XVIIA1
Steroid 17 alpha hydroxylase/17,20 lyase
Steroid 17 alpha monooxygenase
FunctionConversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty.
PathwayLipid metabolism; steroid biosynthesis.
Involvement in diseaseDefects in CYP17A1 are the cause of adrenal hyperplasia type 5 (AH5) [MIM:202110]. AH5 is a form of congenital adrenal hyperplasia, a common recessive disease due to defective synthesis of cortisol. Congenital adrenal hyperplasia is characterized by androgen excess leading to ambiguous genitalia in affected females, rapid somatic growth during childhood in both sexes with premature closure of the epiphyses and short adult stature. Four clinical types: "salt wasting" (SW, the most severe type), "simple virilizing" (SV, less severely affected patients), with normal aldosterone biosynthesis, "non-classic form" or late onset (NC or LOAH), and "cryptic" (asymptomatic).
Sequence similaritiesBelongs to the cytochrome P450 family.
Post-translational modificationsPhosphorylation is necessary for 17,20-lyase, but not for 17-alpha-hydroxylase activity.