The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Dapper antagonist of beta catenin homolog 1
Dapper antagonist of catenin 1
Dapper homolog 1
Hepatocellular carcinoma novel gene 3 protein
Heptacellular carcinoma novel gene 3
FunctionPositively regulates DVL2-mediated signaling pathways during development. Binds to DVL2 and impedes the degradation of CTNNB1/beta-catenin, thereby enhancing the transcriptional activation of target genes of the Wnt signaling pathway.
Sequence similaritiesBelongs to the dapper family.
DomainThe C-terminal PDZ-binding motif mediates interaction with the PDZ domains of DSH (Dishevelled) family proteins.