Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      C-QVLTKNKDNHN
    • Amino acids
      571 to 581

Associated products

Specifications

Our Abpromise guarantee covers the use of ab48045 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-Dcp1a antibody (ab47998)

  • Form
    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

  • Reconstitution
    Please reconstitute this product in 100ul sterile water.

General Info

  • Alternative names
    • DCP1 decapping enzyme homolog A
    • Dcp1a
    • DCP1A_HUMAN
    • Decapping enzyme hDcp1a
    • Decapping mRNA 1A
    • HSA275986
    • mRNA decapping enzyme 1A
    • mRNA-decapping enzyme 1A
    • Nbla00360
    • Putative protein product of Nbla00360
    • Smad4 interacting transcriptional co activator
    • Smad4-interacting transcriptional co-activator
    • Smad4-interacting transcriptional co-activator
    • SMAD4IP1
    • SMIF
    • Transcription factor SMIF
    see all
  • Function
    Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1.
  • Tissue specificity
    Detected in heart, brain, placenta, lung, skeletal muscle, liver, kidney and pancreas.
  • Sequence similarities
    Belongs to the DCP1 family.
  • Cellular localization
    Cytoplasm > P-body. Nucleus. Co-localizes with NANOS3 in the processing bodies (By similarity). Predominantly cytoplasmic, in processing bodies (PB). Nuclear, after TGFB1 treatment. Translocation to the nucleus depends on interaction with SMAD4.
  • Information by UniProt

References

ab48045 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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