Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceC-QEQLHQLHSRLIS
    • Amino acids1266 to 1278

Associated products

Specifications

Our Abpromise guarantee covers the use of ab23214 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-DCTN1 antibody (ab11806)

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • 150 kDa dynein associated polypeptide
    • 150 kDa dynein-associated polypeptide
    • DAP 150
    • DAP-150
    • DAP150
    • DCTN 1
    • DCTN1
    • DCTN1_HUMAN
    • DP 150
    • DP-150
    • DP150
    • Dynactin 1
    • Dynactin 1 (p150 Glued (Drosophila) homolog)
    • Dynactin 1 (p150 glued homolog Drosophila)
    • Dynactin subunit 1
    • Dynactin1
    • HMN7B
    • p135
    • p150 glued
    • p150 Glued (Drosophila) homolog
    • p150 glued homolog
    • p150(GLUED) DROSOPHILA HOMOLOG OF
    • p150-glued
    • p150glued
    see all
  • FunctionRequired for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. Dynein-dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles.
  • Tissue specificityBrain.
  • Involvement in diseaseDefects in DCTN1 are the cause of distal hereditary motor neuronopathy type 7B (HMN7B) [MIM:607641]; also known as progressive lower motor neuron disease (PLMND). HMN7B is a neuromuscular disorder. Distal hereditary motor neuronopathies constitute a heterogeneous group of neuromuscular disorders caused by selective degeneration of motor neurons in the anterior horn of the spinal cord, without sensory deficit in the posterior horn. The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss. The disease starts with weakness and wasting of distal muscles of the anterior tibial and peroneal compartments of the legs. Later on, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs.
    Defects in DCTN1 are a cause of susceptibility to amyotrophic lateral sclerosis (ALS) [MIM:105400]. ALS is a neurodegenerative disorder affecting upper and lower motor neurons, and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology is likely to be multifactorial, involving both genetic and environmental factors.
    Defects in DCTN1 are the cause of Perry syndrome (PERRYS) [MIM:168605]; also called parkinsonism with alveolar hypoventilation and mental depression. Perry syndrome is a neuropsychiatric disorder characterized by mental depression not responsive to antidepressant drugs or electroconvulsive therapy, sleep disturbances, exhaustion and marked weight loss. Parkinsonism develops later and respiratory failure occurred terminally.
  • Sequence similaritiesBelongs to the dynactin 150 kDa subunit family.
    Contains 1 CAP-Gly domain.
  • Post-translational
    modifications
    Ubiquitinated by a SCF complex containing FBXL5, leading to its degradation by the proteasome.
  • Cellular localizationCytoplasm. Cytoplasm > cytoskeleton.
  • Information by UniProt

References for Human DCTN1 peptide (ab23214)

ab23214 has not yet been referenced specifically in any publications.

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