• NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • Amino acids1128 to 1140

Associated products


Our Abpromise guarantee covers the use of ab23152 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-DDB1 antibody (ab9194)

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • Damage specific DNA binding protein 1
    • Damage-specific DNA-binding protein 1
    • DDB 1
    • DDB p127 subunit
    • Ddb1
    • DDB1_HUMAN
    • DDBa
    • DNA damage binding protein 1
    • DNA damage-binding protein 1
    • DNA damage-binding protein a
    • HBV X-associated protein 1
    • UV damaged DNA binding factor
    • UV damaged DNA binding protein 1
    • UV DDB 1
    • UV DDB1
    • UV-damaged DNA-binding factor
    • UV-damaged DNA-binding protein 1
    • UV-DDB 1
    • X associated protein 1
    • XAP 1
    • XAP-1
    • XAP1
    • Xeroderma pigmentosum group E complementing protein
    • Xeroderma pigmentosum group E-complementing protein
    • XPCe
    • XPE
    • XPE BF
    • XPE binding factor
    • XPE-BF
    • XPE-binding factor
    see all
  • FunctionRequired for DNA repair. Binds to DDB2 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the DCX E3 ubiquitin-protein ligase complex is determined by the variable substrate recognition component recruited by DDB1. DCX(DDB2) (also known as DDB1-CUL4-ROC1, CUL4-DDB-ROC1 and CUL4-DDB-RBX1) may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. DCX(DDB2) also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. DCX(ERCC8) (the CSA complex) plays a role in transcription-coupled repair (TCR). May also play a role in ubiquitination of CDKN1B/p27kip when associated with CUL4 and SKP2.
  • PathwayProtein modification; protein ubiquitination.
  • Sequence similaritiesBelongs to the DDB1 family.
  • Post-translational
    Ubiquitinated by CUL4A. Subsequently degraded by ubiquitin-dependent proteolysis.
  • Cellular localizationCytoplasm. Nucleus. Primarily cytoplasmic. Translocates to the nucleus following UV irradiation and subsequently accumulates at sites of DNA damage.
  • Information by UniProt

References for Human DDB1 peptide (ab23152)

ab23152 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab23152.
Please use the links above to contact us or submit feedback about this product.