Death effector domain-containing DNA-binding protein
Death effector domain-containing protein
Death effector domain-containing testicular protein
DED containing protein FLAME 3
DNA binding death effector domain containing protein 2
DNA-binding death effector domain-containing protein 2
FADD like anti apoptotic molecule 3
RelevanceApoptotic signals are often triggered by cell surface death receptors through protein-protein interactions mediated by conserved domains such as the death effector domain. A novel death effector domain (DED)-containing protein, DEDD2, has been recently identified. Over-expression of DEDD2 in transfected cells induces moderate apoptosis and results in substantial sensitization to apoptosis induced by Fas, TRAIL, and FADD. More recently, it has been shown that DEDD2 can bind caspase-8 and -10 in addition to FLIP but not FADD. Like the related protein DEDD, DEDD2 translocates from the cytosol to the nucleus upon induction of apoptosis, and it has been suggested that DEDD2 may target caspase-8 to the nucleus and that DEDD2 thus plays a critical role in death receptor-induced apoptosis. At least two alternatively spliced transcript variants encoding distinct isoforms have been found for DEDD2.
Cellular localizationNuclear, accumulated in subnuclear structures resembling nucleoli.
References for Human DEDD2 peptide (ab39755)
has not yet been referenced specifically in any publications.
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