Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      ATYSSKARLHVCQKI
    • Amino acids
      245 to 259

Associated products

Specifications

Our Abpromise guarantee covers the use of ab45461 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-DKK2 antibody (ab21187)

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

General Info

  • Alternative names
    • Dickkopf 2
    • Dickkopf gene 2
    • Dickkopf homolog 2
    • Dickkopf related protein 2
    • Dickkopf WNT signaling pathway inhibitor 2
    • Dickkopf-2
    • Dickkopf-related protein 2
    • Dickkopf2
    • DKK 2
    • Dkk-2
    • Dkk2
    • DKK2_HUMAN
    • hDkk 2
    • hDkk-2
    • hDkk2
    see all
  • Function
    Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
  • Tissue specificity
    Expressed in heart, brain, skeletal muscle and lung.
  • Sequence similarities
    Belongs to the dickkopf family.
  • Domain
    The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6.
  • Post-translational
    modifications
    May be proteolytically processed by a furin-like protease.
  • Cellular localization
    Secreted.
  • Information by UniProt

References

ab45461 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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