Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceATYSSKARLHVCQKI
    • Amino acids245 to 259

Associated products

Specifications

Our Abpromise guarantee covers the use of ab45461 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-DKK2 antibody (ab21187)

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

General Info

  • Alternative names
    • Dickkopf 2
    • Dickkopf gene 2
    • Dickkopf homolog 2
    • Dickkopf related protein 2
    • Dickkopf WNT signaling pathway inhibitor 2
    • Dickkopf-2
    • Dickkopf-related protein 2
    • Dickkopf2
    • DKK 2
    • Dkk-2
    • Dkk2
    • DKK2_HUMAN
    • hDkk 2
    • hDkk-2
    • hDkk2
    see all
  • FunctionAntagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
  • Tissue specificityExpressed in heart, brain, skeletal muscle and lung.
  • Sequence similaritiesBelongs to the dickkopf family.
  • DomainThe C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6.
  • Post-translational
    modifications
    May be proteolytically processed by a furin-like protease.
  • Cellular localizationSecreted.
  • Information by UniProt

References for Human DKK2 peptide (ab45461)

ab45461 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab45461.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"