Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      RQHARLRVCQKIEKL
    • Amino acids
      210 to 224

Associated products

Specifications

Our Abpromise guarantee covers the use of ab22902 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-DKK4 antibody (ab2342)

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • Dickkopf 4
    • Dickkopf gene 4
    • Dickkopf homolog 4
    • Dickkopf homolog 4 (Xenopus laevis)
    • Dickkopf related protein 4
    • Dickkopf-4
    • Dickkopf-related protein 4 short form
    • Dickkopf4
    • DKK 4
    • Dkk-4
    • DKK4
    • DKK4_HUMAN
    • hDkk 4
    • hDkk-4
    • hDkk4
    • MGC129562
    • MGC129563
    see all
  • Function
    Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
  • Tissue specificity
    Expressed in cerebellum, T-cells, esophagus and lung.
  • Sequence similarities
    Belongs to the dickkopf family.
  • Domain
    The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6.
  • Post-translational
    modifications
    Appears to be not glycosylated.
    Can be proteolytically processed by a furin-like protease.
  • Cellular localization
    Secreted.
  • Information by UniProt

References

ab22902 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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