Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceC-TTRKQTSVDSGIVQ
    • Amino acids1852 to 1865

Associated products

Specifications

Our Abpromise guarantee covers the use of ab22812 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-DOCK1 antibody (ab1348)

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • 180 kDa protein downstream of CRK
    • Ced5
    • Dedicator of Cytokinesis 1
    • Dedicator of cytokinesis protein 1
    • DOCK 1
    • DOCK 180
    • DOCK1
    • DOCK1_HUMAN
    • DOCK180
    see all
  • FunctionInvolved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1.
  • Tissue specificityHighly expressed in placenta, lung, kidney, pancreas and ovary. Expressed at intermediate level in thymus, testes and colon.
  • Sequence similaritiesBelongs to the DOCK family.
    Contains 1 DHR-1 (CZH-1) domain.
    Contains 1 DHR-2 (CZH-2) domain.
    Contains 1 SH3 domain.
  • DomainThe DHR-2 domain is necessary and sufficient for the GEF activity.
  • Cellular localizationCytoplasm. Membrane. Recruited to membranes via its interaction with phosphatidylinositol 3,4,5-triphosphate.
  • Information by UniProt

References for Human DOCK1 peptide (ab22812)

ab22812 has not yet been referenced specifically in any publications.

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