Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      PQGPAFPEPGTATGS
    • Amino acids
      425 to 439

Associated products

Specifications

Our Abpromise guarantee covers the use of ab39756 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    Blocking - Blocking peptide for Anti-DOK1 antibody (ab8112)

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: 0.02% Sodium Azide
    Constituents: 0.01% BSA, PBS, pH 7.2

General Info

  • Alternative names
    • Docking protein 1
    • Docking protein 1 62kD
    • DOK 1
    • DOK1
    • DOK1_HUMAN
    • Downstream of tyrosine kinase 1
    • p62(dok)
    • P62DOK
    • pp62
    see all
  • Function
    DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.
  • Tissue specificity
    Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells.
  • Sequence similarities
    Belongs to the DOK family. Type A subfamily.
    Contains 1 IRS-type PTB domain.
    Contains 1 PH domain.
  • Domain
    The PTB domain mediates receptor interaction.
  • Post-translational
    modifications
    Constitutively tyrosine-phosphorylated.
    Phosphorylated on tyrosine residues by the insulin receptor kinase. Results in the negative regulation of the insulin signaling pathway.
  • Cellular localization
    Cytoplasm and Cytoplasm > perinuclear region.
  • Information by UniProt

References for Human DOK1 peptide (ab39756)

ab39756 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab39756.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up