Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceC-LHRTETFPAYRSEH
    • Amino acids293 to 306

Associated products

Specifications

Our Abpromise guarantee covers the use of ab45623 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-DOK5 antibody (ab24360)

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

General Info

  • Alternative names
    • chromosome 20 open reading frame 180
    • Docking protein 5
    • DOK 5
    • DOK5
    • DOK5 protein
    • DOK5_HUMAN
    • Downstream of tyrosine kinase 5
    • Insulin receptor substrate 6
    • IRS-6
    • IRS6
    see all
  • FunctionDOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation.
  • Tissue specificityHighest expression in skeletal muscle, lower in brain, heart and kidney. Also detected in activated peripheral blood T-lymphocytes.
  • Sequence similaritiesBelongs to the DOK family. Type B subfamily.
    Contains 1 IRS-type PTB domain.
    Contains 1 PH domain.
  • DomainPTB domain mediates receptor interaction.
  • Post-translational
    modifications
    Phosphorylated on tyrosine residues in response to insulin, IGF1 and GDNF.
  • Information by UniProt

References for Human DOK5 peptide (ab45623)

ab45623 has not yet been referenced specifically in any publications.

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