Human DPYD full length protein (ab114584)
- Product nameHuman DPYD full length proteinSee all DPYD proteins and peptides ...
- SourceWheat germ
- Amino Acid Sequence
- SequenceMAPVLSKDSADIESILALNPRTQTHATLCSTSAKKLDKKH WKRNPDKNCFNCEKLENNFDDIKHTTLGERGALREAMRCL KCADAPCQKSCPTNLDIKSFITSIANKNYYGAAKMIFSDN PLGLTCGMVCPTSDLCVGGCNLYATEEGPINIGGLQQFAT ETLILAFSLMNHL
- Molecular weight45 kDa including tags
- Amino acids1 to 173
Our Abpromise guarantee covers the use of ab114584 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- Additional NotesProtein concentration is above or equal to 0.05 µg/ul. Best use within three months from the date of receipt of this protein.
- Concentration information loading...
Preparation and Storage
- Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
Constituents: 0.3% Glutathione, 0.79% Tris HCl
- Dihydropyrimidine dehydrogenase
- Dihydropyrimidine dehydrogenase [NADP(+)]
- Dihydropyrimidine dehydrogenase [NADP+]
- Dihydrothymine dehydrogenase
- Dihydrouracil dehydrogenase
- FunctionInvolved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil.
- Tissue specificityFound in most tissues with greatest activity found in liver and peripheral blood mononuclear cells.
- PathwayAmino-acid biosynthesis; beta-alanine biosynthesis.
- Involvement in diseaseDefects in DPYD are the cause of dihydropyrimidine dehydrogenase deficiency (DPYD deficiency) [MIM:274270]; also known as hereditary thymine-uraciluria or familial pyrimidinemia. DPYD deficiency is a disease characterized by persistent urinary excretion of excessive amounts of uracil, thymine and 5-hydroxymethyluracil. Patients suffering from this disease show a severe reaction to the anticancer drug 5-fluorouracil. This reaction includes stomatitis, Leukopenia, thrombocytopenia, hair loss, diarrhea, fever, marked weight loss, cerebellar ataxia, and neurologic symptoms, progressing to semicoma.
- Sequence similaritiesBelongs to the dihydropyrimidine dehydrogenase family.
Contains 3 4Fe-4S ferredoxin-type domains.
- Cellular localizationCytoplasm.
Human DPYD full length protein images
12.5% SDS-PAGE showing ab114584 at approximately 45.03kDa stained with Coomassie Blue.
References for Human DPYD full length protein (ab114584)
ab114584 has not yet been referenced specifically in any publications.