Overview

Description

  • NatureRecombinant
  • SourceE. coli
  • Amino Acid Sequence
    • SpeciesHuman
    • Amino acids0 to 0

Specifications

Our Abpromise guarantee covers the use of ab83026 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Western blot

  • Purity> 95 % by SDS-PAGE.

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Store at -20°C. Stable for 12 months at -20°C

    Preservative: None
    Constituents: 50% Glycerol, PBS, pH 7.2

General info

  • Alternative names
    • cytokine receptor
    • EBI3
    • EBV induced gene 3 protein
    • EBV-induced gene 3 protein
    • Epstein Barr virus induced 3
    • Epstein Barr virus induced gene 3
    • Epstein Barr virus induced gene 3 protein
    • Epstein-Barr virus induced gene 3
    • Epstein-Barr virus- induced gene 3 protein
    • Epstein-Barr virus-induced gene 3 protein
    • IL 27 subunit beta
    • IL 27B
    • IL-27 subunit beta
    • IL-27B
    • IL27 subunit
    • IL27 subunit beta
    • IL27B
    • IL27B_HUMAN
    • IL35 subunit
    • interleukin 27 subunit beta
    • Interleukin-27 subunit beta
    see all
  • FunctionCytokine with pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines.
  • Sequence similaritiesBelongs to the type I cytokine receptor family. Type 3 subfamily.
    Contains 2 fibronectin type-III domains.
  • Cellular localizationSecreted.
  • Target information above from: UniProt accession Q14213 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

Human EBI3 full length protein images

  • SDS-PAGE showing ab83026.
  • Anti-EBI3 antibody (ab72330) at 2 µg/ml + Human EBI3 full length protein (ab83026) at 0.1 µg

    Secondary
    Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilution
    developed using the ECL technique

    Performed under reducing conditions.

    Exposure time : 8 minutes

References for Human EBI3 full length protein (ab83026)

ab83026 has not yet been referenced specifically in any publications.

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