Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
Evolutionarily conserved signaling intermediate in Toll pathways
Likely ortholog of mouse signaling intermediate in Toll pathway evolutionarily conserved
Signaling intermediate in Toll pathway evolutionarily conserved
FunctionAdapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development (By similarity). Required for efficient assembly of mitochondrial NADH:ubiquinone oxidoreductase.