The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-EDD antibody (ab4376)
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
E3 identified by differential display
E3 ubiquitin protein ligase, HECT domain containing, 1
E3 ubiquitin-protein ligase
E3 ubiquitin-protein ligase UBR5
HECT domain-containing 1
Hyperplastic discs protein homolog
Hyperplastic discs, Drosophila, homolog of
Progestin induced protein
Ubiquitin protein ligase
Ubiquitin protein ligase E3 component n recognin 5
FunctionE3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific amino-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). May be involved in maturation and/or transcriptional regulation of mRNA. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development.
Tissue specificityWidely expressed. Most abundant in testis and expressed at high levels in brain, pituitary and kidney.
PathwayProtein modification; protein ubiquitination.