Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      SHPQKDDGDNPETI
    • Amino acids
      359 to 372

Associated products

Specifications

Our Abpromise guarantee covers the use of ab39763 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Neutralising

    Blocking - Blocking peptide for Anti-EDG1 antibody (ab11424)

  • Purity
    > 90 % SDS-PAGE.

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

General Info

  • Alternative names
    • CD363
    • CHEDG 1
    • CHEDG1
    • D1S3362
    • ECGF 1
    • ECGF1
    • EDG 1
    • EDG1
    • endothelial differentiation G protein coupled receptor 1
    • Endothelial differentiation G-protein coupled receptor 1
    • Endothelial differentiation sphingolipid G protein coupled receptor 1
    • FLJ58121
    • G protein coupled sphingolipid receptor
    • g protein-coupled receptor edg-1
    • S1P receptor 1
    • S1P receptor Edg 1
    • S1P receptor Edg-1
    • S1P receptor Edg1
    • S1P(1) receptor
    • S1P1
    • s1pr1
    • S1PR1_HUMAN
    • sphingolipid g-protein-coupled receptor 1
    • Sphingosine 1 phosphate receptor Edg 1
    • Sphingosine 1 phosphate receptor EDG1
    • sphingosine 1- phosphate receptor 1
    • Sphingosine 1-phosphate receptor 1
    • Sphingosine 1-phosphate receptor Edg-1
    • Sphingosine 1phosphate receptor type 1 S1P1
    see all
  • Function
    Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. This inducible epithelial cell G-protein-coupled receptor may be involved in the processes that regulate the differentiation of endothelial cells. Seems to be coupled to the G(i) subclass of heteromeric G proteins.
  • Tissue specificity
    Endothelial cells, and to a lesser extent, in vascular smooth muscle cells, fibroblasts, melanocytes, and cells of epithelioid origin.
  • Sequence similarities
    Belongs to the G-protein coupled receptor 1 family.
  • Post-translational
    modifications
    S1P-induced endothelial cell migration requires the PKB/AKT1-mediated phosphorylation of the third intracellular loop at the Thr-236 residue.
  • Cellular localization
    Cell membrane.
  • Information by UniProt

References

This product has been referenced in:

See 1 Publication for this product

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