Endothelial differentiation sphingolipid G protein coupled receptor 1
G protein coupled sphingolipid receptor
g protein-coupled receptor edg-1
S1P receptor 1
S1P receptor Edg 1
S1P receptor Edg-1
S1P receptor Edg1
sphingolipid g-protein-coupled receptor 1
Sphingosine 1 phosphate receptor Edg 1
Sphingosine 1 phosphate receptor EDG1
sphingosine 1- phosphate receptor 1
Sphingosine 1-phosphate receptor 1
Sphingosine 1-phosphate receptor Edg-1
Sphingosine 1phosphate receptor type 1 S1P1
FunctionReceptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. This inducible epithelial cell G-protein-coupled receptor may be involved in the processes that regulate the differentiation of endothelial cells. Seems to be coupled to the G(i) subclass of heteromeric G proteins.
Tissue specificityEndothelial cells, and to a lesser extent, in vascular smooth muscle cells, fibroblasts, melanocytes, and cells of epithelioid origin.
Sequence similaritiesBelongs to the G-protein coupled receptor 1 family.
Post-translational modificationsS1P-induced endothelial cell migration requires the PKB/AKT1-mediated phosphorylation of the third intracellular loop at the Thr-236 residue.