Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequencePKEPSNYDFVYDCN
    • Amino acids714 to 727

Associated products

Specifications

Our Abpromise guarantee covers the use of ab22878 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-ELMO1 antibody (ab2239)

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • CED 12
    • Ced 12 homolog
    • Ced 12 homolog 1
    • CED-12
    • CED12
    • Ced12 homolog
    • Ced12 homolog 1
    • ELMO 1
    • ELMO-1
    • Elmo1
    • ELMO1_HUMAN
    • Engulfment and cell motility 1
    • Engulfment and cell motility protein 1
    • KIAA0281
    • MGC126406
    • Protein ced-12 homolog
    see all
  • FunctionInvolved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.
  • Tissue specificityWidely expressed, with a higher expression in the spleen and placenta.
  • Sequence similaritiesContains 1 ELMO domain.
    Contains 1 PH domain.
  • Post-translational
    modifications
    Phosphorylated by HCK.
  • Cellular localizationCytoplasm. Cell membrane. Translocation to plasma membrane seems to be mediated by DOCK1 and CRK.
  • Information by UniProt

References for Human ELMO1 peptide (ab22878)

ab22878 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab22878.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"