Human Ephrin B2 protein fragment (ab92862)

Overview

Description

  • NatureRecombinant
  • SourceHEK 293 cells
  • Amino Acid Sequence
    • SpeciesHuman
    • Amino acids1 to 227

Specifications

Our Abpromise guarantee covers the use of ab92862 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

    SDS-PAGE

  • FormLiquid
  • Additional NotesAfter reconstitution, store in working aliquots at -80ºC.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: PBS, pH 7.4

General info

  • Alternative names
    • EFN B2
    • EFNB 2
    • EFNB2
    • EFNB2_HUMAN
    • Eph related receptor tyrosine kinase ligand 5
    • EPH-related receptor tyrosine kinase ligand 5
    • ephrin B2
    • Ephrin-B2
    • EphrinB2
    • EPLG 5
    • EPLG5
    • Htk L
    • HTK ligand
    • HTK-L
    • HTKL
    • LERK 5
    • LERK-5
    • LERK5
    • Ligand of eph related kinase 5
    • MGC126226
    • MGC126227
    • MGC126228
    • OTTMUSP00000024973
    see all
  • FunctionCell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons.
  • Tissue specificityLung and kidney.
  • Sequence similaritiesBelongs to the ephrin family.
    Contains 1 ephrin RBD (ephrin receptor-binding) domain.
  • Post-translational
    modifications
    Inducible phosphorylation of tyrosine residues in the cytoplasmic domain.
  • Cellular localizationMembrane.
  • Information by UniProt

Human Ephrin B2 protein fragment images

  • 10% SDS-PAGE of ab92862 stained with Coomassie Blue (CB) and immunoblotted with polyclonal antibody against Human Ephrin B2 (WB)

References for Human Ephrin B2 protein fragment (ab92862)

ab92862 has not yet been referenced specifically in any publications.

Product Wall

Purity: ³95% (SDS-PAGE)

Expressed in HEK293 cells

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Thank you for your enquiry.

Yes, it is the fusion protein (472 aa with tag, MWt 52.9kDa) that is at 1mg/ml concentration. The mass of the fusion protein includes the 6x His tag.

I hope this is helpful. Please contact me again if you...

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Vielen Dank für Ihre Geduld! Endlich (!) hat das Labor, welches ab92862 herstellt, sich mit der Information zur Konstruktion des Ephrin B2-Fc-Chimärproteins gemeldet. Es besteht vom N- zum C-Terminus aus: EphrinB2 -IgG1Fc -Histag (Details siehe An...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"