Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceGVLAASMEAKASSQQEKEDKPAETKKLRIAWPPPTELGSSGSALEEGIKM

Associated products

Specifications

Our Abpromise guarantee covers the use of ab111676 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-EPLIN antibody (ab50196)

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • 1110021C24Rik
    • Epithelial protein lost in neoplasm
    • Epithelial protein lost in neoplasm beta
    • EPLIN
    • FLJ38853
    • LIM domain and actin binding 1
    • LIM domain and actin binding protein 1
    • LIM domain and actin-binding protein 1
    • LIMA1
    • LIMA1_HUMAN
    • MGC131726
    • SREBP3
    • Sterol regulatory element binding protein 3
    see all
  • FunctionBinds to actin monomers and filaments. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments.
  • Tissue specificityHighly expressed in placenta, kidney, pancreas, prostate, ovary, spleen and heart. Also detected in lung, liver, brain, skeletal muscle, thymus, testis and intestine. Not detected in leukocytes. Isoform Beta expressed generally at very low levels. Isoform Alpha abundant in epithelial cells from mammary gland, prostate and in normal oral keratinocytes. Low levels in aortic endothelial cells and dermal fibroblasts. Not detectable in myocardium.
  • Sequence similaritiesContains 1 LIM zinc-binding domain.
  • DomainContains at least 2 actin-binding domains, one on each side of the LIM domain. Both domains bind actin monomers and filaments. The C-terminal domain binds filaments more efficiently than the N-terminus.
  • Cellular localizationCytoplasm. Cell junction > focal adhesion. Cytoplasm > cytoskeleton. This cytoskeletal protein co-localizes with actin stress fibers and focal adhesion plaques.
  • Information by UniProt

References for Human EPLIN peptide (ab111676)

ab111676 has not yet been referenced specifically in any publications.

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