Upon binding to EGF receptor enhances EGF-dependent mitogenic signals. Can bind multiple cellular targets.
Expressed in all tissues analyzed, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Expressed in all epithelial and fibroblastic lines examined and in some, but not all, hematopoietic cells.
Belongs to the EPS8 family. Contains 1 PH domain. Contains 1 SH3 domain.
The SH3 domain mediates interaction with SHB.
Phosphorylated by several receptor tyrosine kinases.