Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceYGSARSVGKVEPS-C (N-Terminus)

Associated products

Specifications

Our Abpromise guarantee covers the use of ab45484 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-ERC1 antibody (ab21192)

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

General Info

  • Alternative names
    • Cast 2
    • CAST2
    • CAZ associated structural protein 2
    • Elks
    • ELKS/RAB6 interacting/CAST family member 1
    • ELKS/RAB6-interacting/CAST family member 1
    • ERC 1
    • ERC protein 1
    • ERC-1
    • Erc1
    • ERC1 protein
    • KIAA1081
    • MGC12974
    • RAB6 interacting protein 2
    • RAB6-interacting protein 2
    • RAB6IP2
    • RB6I2_HUMAN
    see all
  • FunctionRegulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport.
  • Tissue specificityWidely expressed. Isoform 2 and isoform 4 are abundantly expressed in brain. Isoform 1 and isoform 3 are predominantly expressed in testis and thyroid, and isoform 1 predominates in other tissues tested.
  • Involvement in diseaseThyroid papillary carcinoma (TPC) [MIM:188550]: A common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. Note=The gene represented in this entry may be involved in disease pathogenesis. A chromosomal aberration involving ERC1/RAB6IP2 is found in cause of thyroid papillary carcinomas. Translocation t(10;12)(q11;p13) involving RET. In vitro, isoform 1, isoform 3 and isoform 5 participating in a ERC1-RET fusion protein activate tyrosine-protein kinase activity.
  • Sequence similaritiesContains 1 FIP-RBD domain.
  • Cellular localizationCytoplasm. Membrane. Golgi apparatus membrane. In neurons, localized closed to presynaptic membrane. Recruited on Golgi membranes by RAB6A in a GTP-dependent manner.
  • Information by UniProt

References for Human ERC1 peptide (ab45484)

ab45484 has not yet been referenced specifically in any publications.

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