Human Estrogen Related Receptor alpha peptide (ab39777)

Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceMSSQVVGIEPLYIKAE
    • Amino acids1 to 16

Specifications

Our Abpromise guarantee covers the use of ab39777 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Neutralising

    Blocking - Blocking peptide for Anti-Estrogen Related Receptor alpha antibody - ChIP Grade (ab16363)

  • Purity> 90 % SDS-PAGE.
    This peptide is greater than 70% pure.
  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Double distilled water or equivalent after reconstitution.

General Info

  • Alternative names
    • Err 1
    • ERR a
    • ERR alpha
    • ERR-alpha
    • Err1
    • ERR1 protein
    • ERR1_HUMAN
    • ERRa
    • ERRalpha
    • ESRL 1
    • ESRL1
    • ESRR A
    • Esrra
    • Estrogen receptor like 1
    • Estrogen receptor related 1
    • estrogen receptor related receptor alpha
    • Estrogen receptor-like 1
    • Estrogen related receptor alpha
    • Estrogen-related receptor alpha
    • Estrra
    • hERR1
    • NR3B1
    • Nuclear receptor subfamily 3 group B member 1
    • Steroid hormone receptor ERR1
    see all
  • FunctionBinds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism.
  • Sequence similaritiesBelongs to the nuclear hormone receptor family. NR3 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • Post-translational
    modifications
    Phosphorylation on Ser-19 enhances sumoylation on Lys-14 increasing repression of transcriptional activity.
    Sumoylated by SUMO2. Main site is Lys-14 which is enhanced by phosphorylation on Ser-19, cofactor activation, and by interaction with PIAS4. Sumoylation enhances repression of transcriptional activiy, but has no effect on subcellular location nor on DNA binding.
  • Cellular localizationNucleus.
  • Information by UniProt

References for Human Estrogen Related Receptor alpha peptide (ab39777)

ab39777 has not yet been referenced specifically in any publications.

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