Human Factor IX full length protein (ab62544)
- Product nameHuman Factor IX full length proteinSee all Factor IX proteins and peptides ...
- Amino Acid Sequence
- Amino acids0 to 0
Our Abpromise guarantee covers the use of ab62544 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- Concentration information loading...
Preparation and Storage
- Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Constituents: 50% Glycerol, 50% H2O
- Christmas Disease
- Christmas factor
- Coagulant factor IX
- Coagulation factor 9
- Coagulation factor IX
- Coagulation factor IX (plasma thromboplastic component)
- Coagulation factor IXa heavy chain
- Factor 9
- Factor IX Deficiency
- GLA domain
- Haemophilia B
- Plasma thromboplastic component
- Plasma thromboplastin component
- Truncated coagulation factor IX
- FunctionFactor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa.
- Tissue specificitySynthesized primarily in the liver and secreted in plasma.
- Involvement in diseaseDefects in F9 are the cause of recessive X-linked hemophilia B (HEMB) [MIM:306900]; also known as Christmas disease.
Note=Mutations in position 43 (Oxford-3, San Dimas) and 46 (Cambridge) prevents cleavage of the propeptide, mutation in position 93 (Alabama) probably fails to bind to cell membranes, mutation in position 191 (Chapel-Hill) or in position 226 (Nagoya OR Hilo) prevent cleavage of the activation peptide.
Defects in F9 are the cause of thrombophilia due to factor IX defect (THR-FIX) [MIM:300807]. A hemostatic disorder characterized by a tendency to thrombosis.
- Sequence similaritiesBelongs to the peptidase S1 family.
Contains 2 EGF-like domains.
Contains 1 Gla (gamma-carboxy-glutamate) domain.
Contains 1 peptidase S1 domain.
- DomainCalcium binds to the gamma-carboxyglutamic acid (Gla) residues and, with stronger affinity, to another site, beyond the Gla domain.
modificationsActivated by factor XIa, which excises the activation peptide.
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
- Cellular localizationSecreted.
Human Factor IX full length protein images
References for Human Factor IX full length protein (ab62544)
ab62544 has not yet been referenced specifically in any publications.