Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      VFSNNDEGLINKK-C
    • Amino acids
      2 to 14

Associated products

Specifications

Our Abpromise guarantee covers the use of ab23301 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-FBXL2 antibody (ab17018)

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • DKFZP564P0622
    • F box and leucine rich repeat protein 2
    • F box protein containing leucine rich repeats
    • F box protein FBL2/FBL3
    • F box/LRR repeat protein 2
    • F-box and leucine-rich repeat protein 2
    • F-box protein FBL2/FBL3
    • F-box/LRR-repeat protein 2
    • FBL 2
    • FBL 3
    • FBL2
    • FBL3
    • FBXL 2
    • FBXL2
    • FBXL2_HUMAN
    see all
  • Function
    Calcium-activated substrate recognition component of a SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 doesn't seem to target phosphodegron within its substrates but rather calmodulin-binding motifs. Targets PCYT1A for its monoubiquitination and degradation, this is antagonized by calmodulin (By similarity). Targets the cyclins CCND2 and CCND3 for polyubiquitination and degradation, leading to cell-cycle arrest in G(0), also antagonized by calmodulin. Binds to hepatitis C virus non-structural protein 5A (NS5A) in a reaction crucial for hepatitis C virus RNA replication.
  • Tissue specificity
    Expressed in brain, heart, kidney, liver, lung, pancreas and placenta.
  • Sequence similarities
    Contains 1 F-box domain.
    Contains 13 LRR (leucine-rich) repeats.
  • Cellular localization
    Membrane.
  • Information by UniProt

References

ab23301 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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