Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceC-EAAQSPYRAVVQIF
    • Amino acids280 to 293

Specifications

Our Abpromise guarantee covers the use of ab23100 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • F box protein that recognizes sugar chains 2
    • F box G domain protein 2
    • F box only protein 6
    • F box protein 6
    • F box protein FBG2
    • F box protein Fbx6
    • F box/G domain protein 2
    • F-box only protein 6
    • F-box protein that recognizes sugar chains 2
    • F-box/G-domain protein 2
    • FBG 2
    • FBG2
    • FBS 2
    • FBS2
    • FBX 6
    • FBX6
    • FBX6_HUMAN
    • FBXO 6
    • FBXO6
    • OTTHUMP00000002267
    see all
  • FunctionSubstrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranlocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication.
  • PathwayProtein modification; protein ubiquitination.
  • Sequence similaritiesContains 1 F-box domain.
    Contains 1 FBA (F-box associated) domain.
  • Cellular localizationCytoplasm.
  • Information by UniProt

References for Human FbxO6 peptide (ab23100)

ab23100 has not yet been referenced specifically in any publications.

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