The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Fem-1-like death receptor-binding protein alpha
Fem-1-like in apoptotic pathway protein alpha
Fem1 homolog b
FEM1 like death receptor binding protein
Protein fem-1 homolog B
FunctionComponent of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1.
Tissue specificityWidely expressed. Highly expressed in testis. Weakly expressed in other tissues.
PathwayProtein modification; protein ubiquitination.
Sequence similaritiesBelongs to the fem-1 family. Contains 8 ANK repeats. Contains 1 TPR repeat.
Cellular localizationCytoplasm. Nucleus. In the nucleus, the protein level increased slightly after camptothecin (CPT) treatment. Associated with chromatin.