Overview

  • Product name
    Human FGD1 peptide

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      C-TAEPPESPQTRDKT
    • Amino acids
      948 to 961

Specifications

Our Abpromise guarantee covers the use of ab45555 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

General Info

  • Alternative names
    • AAS
    • Faciogenital dysplasia 1 protein
    • FGD1
    • FGD1_HUMAN
    • FGDY
    • FYVE RhoGEF and PH domain containing protein 1
    • FYVE, RhoGEF and PH domain-containing protein 1
    • Rho/Rac GEF
    • Rho/Rac guanine nucleotide exchange factor FGD1
    • ZFYVE3
    • Zinc finger FYVE domain containing protein 3
    • Zinc finger FYVE domain-containing protein 3
    see all
  • Function
    Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape.
  • Tissue specificity
    Expressed in fetal heart, brain, lung, kidney and placenta. Less expressed in liver; adult heart, brain, lung, pancreas and skeletal muscle.
  • Involvement in disease
    Aarskog-Scott syndrome
    Defects in FGD1 are found in a patient with non-syndromal X-linked mental retardation.
  • Sequence similarities
    Contains 1 DH (DBL-homology) domain.
    Contains 1 FYVE-type zinc finger.
    Contains 2 PH domains.
  • Domain
    The DH domain is involved in interaction with CCPG1.
  • Cellular localization
    Cytoplasm. Cell projection, lamellipodium. Cell projection, ruffle. Cytoplasm, cytoskeleton. Associated with membrane ruffles and lamellipodia.
  • Information by UniProt

References

ab45555 has not yet been referenced specifically in any publications.

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