The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
CASP8 and FADD like apoptosis regulator
CASP8 and FADD-like apoptosis regulator subunit p12
Caspase like apoptosis regulatory protein
Caspase related inducer of apoptosis
Caspase-like apoptosis regulatory protein
Cellular FLICE-like inhibitory protein
FADD like anti apoptotic molecule
FADD-like antiapoptotic molecule 1
Inhibitor of FLICE
MACH-related inducer of toxicity
FunctionApoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.
Tissue specificityWidely expressed. Higher expression in skeletal muscle, pancreas, heart, kidney, placenta, and peripheral blood leukocytes. Also detected in diverse cell lines. Isoform 8 is predominantly expressed in testis and skeletal muscle.
Sequence similaritiesBelongs to the peptidase C14A family. Contains 2 DED (death effector) domains.
DomainThe caspase domain lacks the active sites residues involved in catalysis.
Post-translational modificationsProteolytically processed; probably by caspase-8. Processing likely occurs at the DISC and generates subunit p43 and p12.