Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceRTSGAFVYDCSKF
    • Amino acids541 to 553

Associated products

Specifications

Our Abpromise guarantee covers the use of ab23069 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-FOXC1 antibody - ChIP Grade (ab5079)

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • ARA
    • FKH L7
    • FKHL 7
    • FKHL7
    • Forkhead (Drosophila) like 7
    • Forkhead box C1
    • Forkhead box protein C1
    • Forkhead drosophila homolog like 7
    • Forkhead like 7
    • Forkhead related activator 3
    • Forkhead related protein FKHL7
    • Forkhead related transcription factor 3
    • Forkhead-related protein FKHL7
    • Forkhead-related transcription factor 3
    • FOX C1
    • FOXC 1
    • Foxc1
    • FOXC1_HUMAN
    • FREAC 3
    • FREAC-3
    • FREAC3
    • IGDA
    • IHG 1
    • IHG1
    • IRID 1
    • IRID1
    • Iridogoniodysgenesis type 1
    • Myeloid factor delta
    see all
  • FunctionBinding of FREAC-3 and FREAC-4 to their cognate sites results in bending of the DNA at an angle of 80-90 degrees.
  • Tissue specificityExpressed in all tissues and cell lines examined.
  • Involvement in diseaseDefects in FOXC1 are the cause of Axenfeld-Rieger syndrome type 3 (RIEG3) [MIM:602482]; also known as Axenfeld-Rieger syndrome (ARS) or Axenfeld syndrome or Axenfeld anomaly. It is characterized by posterior corneal embryotoxon, prominent Schwalbe line and iris adhesion to the Schwalbe line. Other features may be hypertelorism (wide spacing of the eyes), hypoplasia of the malar bones, congenital absence of some teeth and mental retardation. When associated with tooth anomalies, the disorder is known as Rieger syndrome. Glaucoma is a progressive blinding condition that occurs in approximately half of patients with Axenfeld-Rieger malformations.
    Defects in FOXC1 are the cause of iridogoniodysgenesis anomaly (IGDA) [MIM:601631]. IGDA is an autosomal dominant phenotype characterized by iris hypoplasia, goniodysgenesis, and juvenile glaucoma.
    Defects in FOXC1 are a cause of Peters anomaly (PAN) [MIM:604229]. Peters anomaly consists of a central corneal leukoma, absence of the posterior corneal stroma and Descemet membrane, and a variable degree of iris and lenticular attachments to the central aspect of the posterior cornea.
  • Sequence similaritiesContains 1 fork-head DNA-binding domain.
  • Cellular localizationNucleus.
  • Information by UniProt

References for Human FOXC1 peptide (ab23069)

ab23069 has not yet been referenced specifically in any publications.

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