Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceRHAAPYSYDCTKY
    • Amino acids489 to 501

Associated products

Specifications

Our Abpromise guarantee covers the use of ab23061 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-FOXC2 antibody - ChIP Grade (ab5060)

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • Drosphilia Forkhead Homolog Like 14
    • FKHL 14
    • FKHL14
    • Forkhead Box C2
    • Forkhead box protein C2
    • Forkhead related protein FKHL14
    • Forkhead-related protein FKHL14
    • FOX C2
    • Foxc2
    • FOXC2_HUMAN
    • LD
    • Mesenchyme fork head protein 1
    • Mesenchyme Forkhead 1
    • MFH 1
    • MFH 1 protein
    • MFH-1 protein
    • MFH1
    • Transcription factor FKH 14
    • Transcription factor FKH-14
    see all
  • FunctionTranscriptional activator. Might be involved in the formation of special mesenchymal tissues.
  • Involvement in diseaseDefects in FOXC2 are the cause of lymphedema hereditary type 2 (LMPH2) [MIM:153200]; also known as Meige lymphedema. Hereditary lymphedema is a chronic disabling condition which results in swelling of the extremities due to altered lymphatic flow. Patients with lymphedema suffer from recurrent local infections, and physical impairment.
    Defects in FOXC2 are a cause of lymphedema-yellow nails (LYYN) [MIM:153300]. LYYN is characterized by yellow, dystrophic, thick and slowly growing nails, associated with lymphedema and respiratory involvement. Lymphedema occurs more often in the lower limbs. It can appear at birth or later in life. Onset generally follows the onset of ungual abnormalities.
    Defects in FOXC2 are a cause of lymphedema-distichiasis (LYD) [MIM:153400]. LYD is characterized by primary limb lymphedema usually starting at puberty (but in some cases later or at birth) and associated with distichiasis (double rows of eyelashes, with extra eyelashes growing from the Meibomian gland orifices).
  • Sequence similaritiesContains 1 fork-head DNA-binding domain.
  • Cellular localizationNucleus.
  • Information by UniProt

References for Human FOXC2 peptide (ab23061)

ab23061 has not yet been referenced specifically in any publications.

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