Overview

  • Product nameHuman FOXH1 peptide

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceGPCSGSRLGPPEAE
    • Amino acids2 to 15

Specifications

Our Abpromise guarantee covers the use of ab23092 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • FAST 1
    • Fast 2
    • Fast-1
    • Fast-2
    • FAST1
    • Fast2
    • Forkhead activin signal transducer 1
    • Forkhead activin signal transducer 2
    • Forkhead box H1
    • Forkhead box protein H1
    • FOX H1
    • FOXH 1
    • FOXH1
    • FOXH1_HUMAN
    • hFAST 1
    • hFAST-1
    • hFAST1
    • Human homolog of Xenopus forkhead activin signal transducer 1
    • TGF beta/Activin signal transducer FAST1
    see all
  • FunctionTranscriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element).
  • Tissue specificityUbiquitous.
  • Sequence similaritiesContains 1 fork-head DNA-binding domain.
  • DomainThe FM region is required for binding SMAD2/SMAD4 complexes. FM2 is more effective than FM1 and only interacts with phosphorylated SMAD2 that is in an activated SMAD complex.
  • Cellular localizationNucleus.
  • Information by UniProt

References for Human FOXH1 peptide (ab23092)

ab23092 has not yet been referenced specifically in any publications.

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