Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      C-DNINWSQFIPELQ
    • Amino acids
      751 to 763

Specifications

Our Abpromise guarantee covers the use of ab23253 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • FKHL16
    • Forkhead box M1
    • Forkhead box protein M1
    • forkhead like 16
    • Forkhead-related protein FKHL16
    • FOX M1
    • Foxm1
    • FOXM1_HUMAN
    • FOXM1B
    • Hepatocyte nuclear factor 3 forkhead homolog 11
    • HFH-11
    • HFH11
    • HNF-3/fork-head homolog 11
    • HNF3
    • INS1
    • M phase phosphoprotein 2
    • M-phase phosphoprotein 2
    • MPHOSPH2
    • MPM-2 reactive phosphoprotein 2
    • MPP2
    • PIG29
    • TGT3
    • Transcription factor Trident
    • Trident
    • WIN
    • Winged-helix factor from INS-1 cells
    • Winged-helix factor from INS1 cells
    see all
  • Function
    Transcriptional activatory factor. May play a role in the control of cell proliferation.
  • Tissue specificity
    Expressed in thymus, testis, small intestine, colon followed by ovary. Appears to be expressed only in adult organs containing proliferating/cycling cells or in response to growth factors. Also expressed in epithelial cell lines derived from tumors. Not expressed in resting cells. Isoform 2 is highly expressed in testis.
  • Sequence similarities
    Contains 1 fork-head DNA-binding domain.
  • Developmental stage
    Embryonic expression pattern: liver, lung, intestine, kidney, urinary tract; adult expression pattern: intestine, colon, testis and thymus.
  • Domain
    Within the protein there is a domain which acts as a transcriptional activator. Insertion of a splicing sequence within it inactivates this transcriptional activity, as it is the case for isoform 4.
  • Post-translational
    modifications
    Phosphorylated in M (mitotic) phase.
  • Cellular localization
    Nucleus.
  • Information by UniProt

References

ab23253 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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