Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceC-GAKQASSQSWVPG
    • Amino acids661 to 673

Associated products

Specifications

Our Abpromise guarantee covers the use of ab45581 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-FOXO3A antibody (ab17026)

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

General Info

  • Alternative names
    • AF6q21
    • AF6q21 protein
    • DKFZp781A0677
    • FKHR2
    • FKHRL 1
    • FKHRL1
    • FKHRL1P2
    • Forkhead (Drosophila) homolog (rhabdomyosarcoma) like 1
    • Forkhead box O3
    • Forkhead box O3A
    • Forkhead box protein O3
    • Forkhead box protein O3A
    • Forkhead Drosophila homolog of in rhabdomyosarcoma like 1
    • Forkhead homolog (rhabdomyosarcoma) like 1
    • Forkhead in rhabdomyosarcoma like 1
    • Forkhead in rhabdomyosarcoma-like 1
    • FOX O3A
    • FOXO2
    • foxo3
    • FOXO3_HUMAN
    • FOXO3A
    • MGC12739
    • MGC31925
    see all
  • FunctionTranscriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'.
  • Tissue specificityUbiquitous.
  • Involvement in diseaseNote=A chromosomal aberration involving FOXO3 is found in secondary acute leukemias. Translocation t(6;11)(q21;q23) with MLL/HRX.
  • Sequence similaritiesContains 1 fork-head DNA-binding domain.
  • Post-translational
    modifications
    In the presence of survival factors such as IGF-1, phosphorylated on Thr-32 and Ser-253 by AKT1/PKB. This phosphorylated form then interacts with 14-3-3 proteins and is retained in the cytoplasm. Survival factor withdrawal induces dephosphorylation and promotes translocation to the nucleus where the dephosphorylated protein induces transcription of target genes and triggers apoptosis. Although AKT1/PKB doesn't appear to phosphorylate Ser-315 directly, it may activate other kinases that trigger phosphorylation at this residue. Phosphorylated by STK4 on Ser-209 upon oxidative stress, which leads to dissociation from YWHAB/14-3-3-beta and nuclear translocation. Phosphorylated by PIM1.
  • Cellular localizationCytoplasm > cytosol. Nucleus. Translocates to the nucleus upon oxidative stress and in the absence of survival factors.
  • Information by UniProt

References for Human FOXO3A peptide (ab45581)

ab45581 has not yet been referenced specifically in any publications.

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