Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      C-AAALDLSGRRG
    • Amino acids
      664 to 674

Associated products

Specifications

Our Abpromise guarantee covers the use of ab23166 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-GADD34 antibody (ab9869)

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • Apoptosis associated protein
    • GADD 34
    • Growth arrest and DNA damage inducible 34
    • Growth arrest and DNA damage-inducible protein GADD34
    • Myeloid differentiation primary response protein MyD116 homolog
    • Ppp1r15a
    • PR15A_HUMAN
    • Protein phosphatase 1 regulatory (inhibitor) subunit 15A
    • Protein phosphatase 1 regulatory subunit 15A
    see all
  • Function
    Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'.
  • Sequence similarities
    Belongs to the PPP1R15 family.
  • Post-translational
    modifications
    Phosphorylated on tyrosine by LYN; which impairs its antiproliferative activity.
  • Cellular localization
    Endoplasmic reticulum.
  • Information by UniProt

References

ab23166 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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