The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-GADD34 antibody (ab9869)
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Apoptosis associated protein
Growth arrest and DNA damage inducible 34
Growth arrest and DNA damage-inducible protein GADD34
Myeloid differentiation primary response protein MyD116 homolog
Protein phosphatase 1 regulatory (inhibitor) subunit 15A
Protein phosphatase 1 regulatory subunit 15A
FunctionRecruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'.
Sequence similaritiesBelongs to the PPP1R15 family.
Post-translational modificationsPhosphorylated on tyrosine by LYN; which impairs its antiproliferative activity.