Human gamma Catenin (phospho Y550) peptide (ab42715)

Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • Amino acids0 to 0
    • Modificationsphospho Y550

Specifications

Our Abpromise guarantee covers the use of ab42715 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activityThis peptide sequence is highly conserved in rat and mouse gamma Catenin.
  • Applications

    Western blot

    Immunocytochemistry/ Immunofluorescence

    Blocking

    ELISA

  • Purity> 90 % by SDS-PAGE.

  • FormLiquid
  • Additional NotesThis peptide sequence is highly conserved in rat and mouse gamma Catenin.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: 0.05% Sodium Azide
    Constituents: PBS

General info

  • Alternative names
    • ARVD 12
    • ARVD12
    • Catenin (cadherin associated protein), gamma 80kDa
    • catenin (cadherin-associated protein) gamma (80kD)
    • Catenin gamma
    • CTNNG
    • Desmoplakin 3
    • Desmoplakin III
    • Desmoplakin-3
    • Desmoplakin3
    • DesmoplakinIII
    • DP 3
    • DP III
    • DP3
    • DPIII
    • gamma catenin
    • Junction plakoglobin
    • JUP
    • OTTHUMP00000164732
    • OTTHUMP00000164735
    • OTTHUMP00000164738
    • PDGB
    • PKGB
    • PLAK_HUMAN
    • PLAKOGLOBIN
    see all
  • FunctionCommon junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.
  • Involvement in diseaseDefects in JUP are the cause of Naxos disease (NXD) [MIM:601214]. NXD is an autosomal recessive disorder combining diffuse non-epidermolytic palmoplantar keratoderma with arrhythmogenic right ventricular dysplasia/cardiomyopathy and woolly hair.
    Defects in JUP are the cause of familial arrhythmogenic right ventricular dysplasia type 12 (ARVD12) [MIM:611528]; also called arrhythmogenic right ventricular cardiomyopathy 12 (ARVC12). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall.
  • Sequence similaritiesBelongs to the beta-catenin family.
    Contains 9 ARM repeats.
  • Cellular localizationCell junction > adherens junction. Cell junction > desmosome. Cytoplasm > cytoskeleton. Membrane. Cytoplasmic in a soluble and membrane-associated form.
  • Target information above from: UniProt accession P14923 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

References for Human gamma Catenin (phospho Y550) peptide (ab42715)

ab42715 has not yet been referenced specifically in any publications.

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