Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequencePyr-GPWLEEEEEAGWMDF
    • Amino acids77 to 92

Associated products

Specifications

Our Abpromise guarantee covers the use of ab42257 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-Gastrin antibody (ab14182)

  • FormLyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. After reconstitution store at -20ºC. Avoid freeze / thaw cycles.

  • ReconstitutionResuspend in 60% acetonitrile in 0.01M ammoiumbicarbonate for required concentration (vial content is 0.1 mg).

General Info

  • Alternative names
    • Component II
    • G14
    • G17
    • G34
    • G52
    • G6
    • GAS
    • Gast
    • GAST_HUMAN
    • Gastrin
    • Gastrin component I
    • Gastrin component II
    • Gastrin component III
    • Gastrin precursor
    • Gastrin-14
    • Gastrin-17
    • Gastrin-34
    • Gastrin-52
    • Gastrin-6
    • Gastrin-71
    see all
  • FunctionGastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.
  • Sequence similaritiesBelongs to the gastrin/cholecystokinin family.
  • Post-translational
    modifications
    Two different processing pathways probably exist in antral G-cells. In the dominant pathway progastrin is cleaved at three sites resulting in two major bioactive gastrins, gastrin-34 and gastrin-17. In the putative alternative pathway, progastrin may be processed only at the most C-terminal dibasic site resulting in the synthesis of gastrin-71.
    Sulfation enhances proteolytic processing, and blocks peptide degradation. Levels of sulfation differ between proteolytically-cleaved gastrins. Thus, gastrin-6 is almost 73% sulfated, whereas the larger gastrins are less than 50% sulfated. Sulfation levels are also tissue-specific.
  • Cellular localizationSecreted.
  • Information by UniProt

References for Human Gastrin peptide (ab42257)

ab42257 has not yet been referenced specifically in any publications.

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