Human Gastrin peptide (ab42257)
Key features and details
- Purity: > 95% HPLC
- Suitable for: Blocking
Description
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Product name
Human Gastrin peptide
See all Gastrin proteins and peptides -
Purity
> 95 % HPLC. -
Animal free
No -
Nature
Synthetic -
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Species
Human -
Sequence
Pyr-GPWLEEEEEAGWMDF -
Amino acids
77 to 92
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Associated products
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Corresponding Antibody
Specifications
Our Abpromise guarantee covers the use of ab42257 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
Blocking - Blocking peptide for Anti-Gastrin antibody (ab14182)
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Form
Lyophilized -
Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped at 4°C. After reconstitution store at -20ºC. Avoid freeze / thaw cycles.
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ReconstitutionResuspend in 60% acetonitrile in 0.01M ammoiumbicarbonate for required concentration (vial content is 0.1 mg).
General Info
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Alternative names
- Component II
- G14
- G17
see all -
Function
Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine. -
Sequence similarities
Belongs to the gastrin/cholecystokinin family. -
Post-translational
modificationsTwo different processing pathways probably exist in antral G-cells. In the dominant pathway progastrin is cleaved at three sites resulting in two major bioactive gastrins, gastrin-34 and gastrin-17. In the putative alternative pathway, progastrin may be processed only at the most C-terminal dibasic site resulting in the synthesis of gastrin-71.
Sulfation enhances proteolytic processing, and blocks peptide degradation. Levels of sulfation differ between proteolytically-cleaved gastrins. Thus, gastrin-6 is almost 73% sulfated, whereas the larger gastrins are less than 50% sulfated. Sulfation levels are also tissue-specific. -
Cellular localization
Secreted. - Information by UniProt
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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Datasheet download
References (0)
ab42257 has not yet been referenced specifically in any publications.