Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceGS(X)FLSPEHQRVQQRKESKKPPAKLQPR
    • Amino acids24 to 51

Specifications

Our Abpromise guarantee covers the use of ab51922 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    Western blot

    Blocking

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 0.1% BSA, PBS

General Info

  • Alternative names
    • Appetite regulating hormone
    • Ghrelin
    • Ghrelin 27
    • Ghrelin 28
    • Ghrelin and obestatin prepropeptide
    • Ghrelin/obestatin prepropeptide
    • ghrl
    • GHRL_HUMAN
    • Growth hormone releasing peptide
    • Growth hormone secretagogue
    • Growth hormone-releasing peptide
    • M46 protein
    • Motilin related peptide
    • Motilin-related peptide
    • MTLRP
    • Obestatin
    • Protein M46
    see all
  • FunctionGhrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation.
    Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility.
  • Tissue specificityHighest level in stomach. All forms are found in serum as well. Other tissues compensate for the loss of ghrelin synthesis in the stomach following gastrectomy.
  • Sequence similaritiesBelongs to the motilin family.
  • Post-translational
    modifications
    O-octanoylation or O-decanoylation is essential for ghrelin activity. The O-decanoylated forms Ghrelin-27-C10 and Ghrelin-28-C10 differ in the length of the carbon backbone of the carboxylic acid bound to Ser-26. A small fraction of ghrelin, ghrelin-28-C10:1, may be modified with a singly unsaturated carboxylic acid.
    Amidation of Leu-98 is essential for obestatin activity.
  • Cellular localizationSecreted.
  • Information by UniProt

References for Human Ghrelin peptide (ab51922)

ab51922 has not yet been referenced specifically in any publications.

Product Wall

We do have the human ghrelin 28 peptide modified with n-octanoic acid at serine 3-

http://www.abcam.com/human-ghrelin-peptide-ab51922.html

http://www.abcam.com/human-ghrelin-peptide-ab73131.html

Will one of these peptides wor...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"